Film-Forming Systems for Dermal Drug Delivery
Film-forming formulations represent a novel form of sustained release dermatic products. They are applied to the skin as a liquid or semi-solid preparation. By evaporation of the volatile solvent on the skin, the polymer contained in the formulation forms a solid film. Various film-forming formulations were tested for their water and abrasion resistance and compared with conventional semi-solid formulations. Penetration and permeation studies of the formulations indicate a potential utility as transdermal therapeutic systems. They can be used as an alternative to patch systems to administer a variety of drugs in a topical way and may provide sustained release characteristics.
Download the full article here: Film-Forming Systems for Dermal Drug Delivery
or continue reading here: Pünnel, L.C.; Lunter, D.J. Film-Forming Systems for Dermal Drug Delivery. Pharmaceutics 2021, 13, 932. https://doi.org/10.3390/pharmaceutics13070932
Polymers for use in film-forming formulations
Polymer | Properties |
---|---|
Carbopol (polyacrylat) | water-soluble, pH sensitive |
Chitosan (Poly-D-Glucosamin) | water-soluble at pH < 7 |
Crosslinked polymer layer XPL | adhesive, elastic |
Dermacryl 79 (Carboxylates Acrylpolymer) | water-insoluble |
Ethylcellulose | non-toxic, not irritating, anti-allergic |
Eudragit NE (ethylacrylate methylmethacrylate copolymer) | water-insoluble, transparent, elastic, adhesive |
Eudragit RL-100 (polymethacrylate polymere) | water-insoluble, transparent, elastic, adhesive |
Eudragit RS-100 (polymethacrylate polymere) | water-insoluble, transparent, elastic, adhesive |
Eudragit L30D-55 (methacrylate-ethylacrylate-copolymer) | water dispersible at pH 2–3 |
Hydroxypropyl-beta-cyclodextrin | water-insoluble, increases bioavailability |
Hydroxypropylmethylcellulose (HPMC) | water-soluble, non-ionic |
KIucel (Hydroxypropyl cellulose) | water-soluble, non-ionic |
Macrogol | water-soluble |
Methyl cellulose | water-soluble |
Poloxamer (polyethylenepolypropylene glycol) | thermoreversible |
Plastoid (Butyl methacrylate-methylmethacrylate copolymer) | water-insoluble |
Polydimethylsiloxane (PDMS) | water-insoluble, non-toxic |
Polyvinyl alcohol (PVA) | water-soluble, adhesive, non-toxic |
Polyvinyl pyrrolidine (PVP) | water-soluble, adhesive, increase bioavailability |
Quaternary polymethacrylat (QPM) | water-insoluble |
Sepineo P600 (acrylamide/sodium acryloldimethyltaurate) | water-insoluble |
Silicone | water-soluble, non-occlusive |