Introduction of the energy to break an avalanche as a promising parameter for powder flowability prediction

2. August 2020

Dynamic avalanche testing is a newer method useful even with cohesive powder samples. To evaluate flow properties of pharmaceutical powder...

SEM image of coated gliclazide sustained release microparticles at 25% coating level

Easy to Swallow “Instant” Jelly Formulations for Sustained Release Gliclazide Delivery

18. May 2020

It is a challenge to safely administer sustained release medicines to patients with dysphagia. Sustained release tablets must not be...

Non-Uniform Drug Distribution Matrix System (NUDDMat) for Zero-Order Release of Drugs with Different Solubility

16. March 2020

A decrease in the drug release rate over time typically affects the performance of hydrophilic matrices for oral prolonged release....

Assessment of the effect of Cellets’ particle size on the flow in a Wurster fluid-bed coater via powder rheology

15. March 2020

The main objective of this study was to investigate the effect of microcrystalline cellulose (MCC) spheres (Cellets) size effect on...

Fluidized and Spouted Bed for the preparation of directly processable amorphous solid dispersions

9. March 2020

One of the major challenges for modern formulation development is the increasing number of poorly water-soluble drugs. A common formulation...

Compression of Coated Pellets in Tablets

A Mechanistic Understanding of Compression Damage to the Dissolubility of Coated Pellets in Tablets

6. December 2019

Damage to the drug diffusion coat barrier of controlled release pellets by the compaction force when preparing multiple-unit pellet system...

Schematic illustration of Wurster fluidised bed coating process

Wurster Fluidised Bed Coating of Microparticles: Towards Scalable Production of Oral Sustained-Release Liquid Medicines for Patients with Swallowing Difficulties

16. November 2019

Suspension of microparticles in an easy-to-swallow liquid is one approach to develop sustained-release formulations for children and patients with swallowing...

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