Personalised Tasted Masked Chewable 3D Printed Fruit-Chews for Paediatric Patients

The development of personalised paediatric dosage forms using 3D printing technologies has gained significant interest over the last few years. In the current study extruded filaments of the highly bitter Diphenhydramine Hydrochloride (DPH) were fabricated by using suitable hydrophilic carries such as hydroxypropyl cellulose (Klucel ELF^TM) and a non-ionic surfactant (Gelucire 48/16^TM) combined with sweetener (Sucralose) and strawberry flavour grades. The thermoplastic filaments were used to print 3D fruit-chew designs by Fused Deposition Modelling (FDM) technology. Physicochemical characterisation confirmed the formation of glass solution where DPH was molecularly dispersed within the hydrophilic carriers.

DPH was released rapidly from the 3D printed fruit-chew designs with >85% within the first 30 min. Trained panellists performed a full taste and sensory evaluation of the sweetener intensity and the strawberry aroma. The evaluation showed complete taste masking of the bitter DPH and revealed a synergistic effect of the sweetener and the strawberry flavour with enhanced sweet strawberry, fruity and aftertaste perception. The findings of the study can be used for the development of paediatric dosage forms with enhanced organoleptic properties, palatability and medication adherence.

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or continue reading here: Tabriz, A.G.; Fullbrook, D.H.G.; Vilain, L.; Derrar, Y.; Nandi, U.; Grau, C.; Morales, A.; Hooper, G.; Hiezl, Z.; Douroumis, D. Personalised Tasted Masked Chewable 3D Printed Fruit-Chews for Paediatric Patients. Pharmaceutics 2021, 13, 1301. https://doi.org/10.3390/pharmaceutics13081301

Materials
Diphenhydramine hydrochloride (DPH, purity > 98%) was purchased from Sigma-Aldrich (Rochester, UK). Strawberry flavouring was purchased from Symrise Ltd. (Marlow, UK), sucralose was purchased from Merck Life Science UK Limited (Dorset, UK). Various food grade (yellow, green, blue and red) colourings were purchased from Ash Spice company (Leicester, UK). Gelucire 48/16TM (GLC) and hydroxypropyl cellulose (Klucel ELFTM) were kindly donated by GATTEFOSSE (Lyon, France) and Ashland (Rotterdam, The Netherlands), respectively.