CBD Overview

Abstract Background: Emerging evidence supports cannabidiol (CBD) as a promising therapeutic compound for various health conditions, despite its approval as a medication (product for medical purposes) remaining restricted to a limited range of clinical indications. Simultaneously, the regulation of…
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Abstract Background: Cannabidiol (CBD) is an approved treatment for childhood epilepsies and a candidate treatment for several other CNS disorders. However, it has poor oral bioavailability. We investigated the effect of a novel lipid formulation on its absorption in humans and on its tissue…
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Abstract Introduction: The development of a novel dosage form for cannabis extract is necessary to improve drug delivery and to also enhance patient convenience. Methods: Orally fast disintegrating wafer tablets containing cannabis extract, which were prepared using the freeze drying…
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Δ9-Tetrahydrocannabinol and cannabidiol, which are present in cannabis extract, exhibit low bioavailability when administered orally due to significant first-pass metabolism. The use of a self-emulsifying drug delivery system (SEDDS) can enhance their dissolution and bioavailability. However, liquid…
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Aim of the Study Due to the physico-chemical properties of cannabidiol (CBD), the vast majority of the marketed products containing CBD are oils. To provide greater convenience in dosing, the goal of this experiment was to make directly compressible 25 mg CBD oil tablets as well as  25…
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Abstract Cannabidiol (CBD) has been recognized for its numerous therapeutic benefits, such as neuroprotection, anti-inflammatory effects, and cardioprotection. However, CBD has some limitations, including unpredictable pharmacokinetics and low oral bioavailability. To overcome the challenges…
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Cannabinoids: cannabidiol (CBD), cannabidiolic acid (CBDA), and cannabichromene (CBC) are lipophilic compounds with limited water solubility, resulting in challenges related to their bioavailability and therapeutic efficacy upon oral administration. To overcome these limitations, we developed…
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Cannabidiol (CBD) is a plant-derived cannabinoid found in marijuana and hemp that has been intensely investigated for its putative anti-inflammatory, anxiolytic and/or analgesic effects. Since all these conditions require long-term treatment, sustained release formulations are being investigated.…
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As a complement to vaccines, small-molecule therapeutic agents are needed to treat or prevent infections by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants, which cause COVID-19. Affinity selection–mass spectrometry was used for the discovery of botanical ligands to the…
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Medicinal Cannabinoids There are currently more than 150 cannabinoid-based products under development in the world. The first US FDA approved product Epidiolex®, isolated from the cannabis plant and indicated for severe forms of epilepsy is formulated with Sesame oil. Other approved products like…
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