- Suppliers
ADM 
Antares 
Armor Pharma 
Asahi KASEI 
Ashland 
BASF 
Beneo 
Captisol 
Clariant 
Croda 
DFE Pharma 
Excipio Chemicals 
Fuji Chemical 
Gattefossé 
Gangwal 
IOI Oleo 
Ingredient Pharm 
JRS Pharma 
Kerry 
KLK Oleo 
Lipoid 
Lubrizol Life Science Health 
MAGNESIA 
MEGGLE 
Nagase Viita 
Nordic Bioproducts 
pharm-a-spheres 
PMC Isochem 
Seppic 
ShinEtsu 
Sigachi 
SPI Pharma 
Südzucker 
Vikram Thermo 
Zerion Pharma 
All4Nutra
- Suppliers
ADM Antares Armor Pharma Asahi KASEI Ashland BASF Beneo Captisol Clariant Croda DFE Pharma Excipio Chemicals Fuji Chemical Gattefossé Gangwal IOI Oleo Ingredient Pharm JRS Pharma Kerry KLK Oleo Lipoid Lubrizol Life Science Health MAGNESIA MEGGLE Nagase Viita Nordic Bioproducts pharm-a-spheres PMC Isochem Seppic ShinEtsu Sigachi SPI Pharma Südzucker Vikram Thermo Zerion Pharma - All4Nutra
Repositioning miconazole nitrate for malaria: Formulation of sustained release nanostructured lipid carriers, structure characterization and in vivo antimalarial evaluation
Sustained release nanostructured lipid carriers of Miconazole
It has been previously claimed that miconazole (MNZ) has activity against Plasmodium falciparum in vitro. Therefore, this study aims to evaluate the potential of MNZ as an alternative antimalarial agent. MNZ was entrapped in nanostructured lipid carriers (NLC) based on Softisan®154 and soybean oil admixtures.
Highlights
NLC based on Softisan® 154 and soybean oil had desirable physical properties.
NLC improved aqueous solubility and gastrostability of miconazole (MNZ).
MNZ-NLCs had sustained release and cleared Plasmodium berghei in vivo.
MNZ could be repurposed for the treatment of malaria.
Batches of MNZ-loaded NLC were characterized for particle size and surface charge, differential scanning calorimetry (DSC), x-ray diffractometry (XRD), and encapsulation efficiency (EE%). In vitro release and in vivo antimalarial evaluations (using a murine model) were also carried out. Particle size of NLC ranged from 175 – 525 nm, and surface charge from −20 to −27 mV. DSC thermograms showed amorphization of MNZ at low melting points and enthalpies. X-ray diffractograms showed broader and weaker patterns with few characteristic peaks of MNZ, and high EE% of 90 – 98 % were recorded. In vitro release study showed controlled release effect with about 82 % of MNZ released after 8 h. In vivo clearance of parasitaemia was drug loading-dependent and compared favourably with the positive control. Stability testing of the MNZ-loaded NLC exhibited no significant (p>0.05) changes in EE% compared to initial analysis. Thus, MNZ could be repurposed as an effective alternative for the treatment of malaria. Continue on Repositioning miconazole nitrate for malaria
What is SOFTISAN® 154?
Softisan 154 is a Hydrogenated Palm Oil – Triglycerides with a Melting Point of ~ 57 C° suitable for hot melt coating, similar to hydrogenated vegetable oil. Interested to get more information?
