Hot-melt extrusion

Abstract The development of solid dispersions (SDs) has gained increased attention in recent decades, leading to successful delivery systems for...

Abstract Amorphous solid dispersions (ASDs) make a significant contribution to enhancing the solubility of poorly soluble drugs. The incorporation of...

Abstract Aceclofenac (ACF), a Non-Steroidal Anti-Inflammatory Drug (NSAID), is formulated with Soluplus® (SOLP) to enhance solubility and bioavailability. This study...

Abstract Drug delivery products based on poly(lactic-co-glycolic acid) (PLGA) often have multiphasic drug release profiles with slow “lag phase(s)” and...

Abstract Aim: In addition to numerous benefits provided by nanosuspensions (NSs) (e.g., enhanced saturation solubility, increased area for interaction with fluids),...

Abstract The present study aims to develop capsules employing hot melt extrusion (HME) and fused deposition modeling (FDM) three-dimensional (3D)...

Abstract Solid eutectic mixtures of self-dispersible polyethylene glycol-40-stearate with fenofibrate or ibuprofen—prepared by casting or by twin-screw extrusion—were compared in...

Abstract With the implementation of advanced manufacturing concepts (e.g., continuous operation, integration of different process routes and modular manufacturing), control...

Abstract In the last decades, tremendous improvements have been made in enhancing the bioavailability of poorly soluble active pharmaceutical ingredients...

Abstract Given the recurrent waves of COVID-19 and the emergence of new viral infections, optimizing the potential of remdesivir as...