Comparative Study of the Mucoadhesive Properties of Polymers for Pharmaceutical Use
In recent years, mucoadhesive dosage forms due to their advantages have attracted the interest of researchers and developers. Polymeric excipients are included into the drug composition to give adhesion to the mucous membrane.
AIM: The aim of this research was to select a specific brand of pharmaceutical quality polymer that is promising for inclusion in the drug formulation.
METHODS: The article presents the results of studying the mucoadhesive properties of polymers on two models using mucin: By measuring the amount of adhesion and by the evaluation the sample movement speed.
RESULTS: According to the combination of two indicators, the highest mucoadhesive properties were shown by the brands of hydroxypropylmethylcellulose and xanthan gum. In addition, it was noted that hydroxyethylcellulose (HEC), sodium alginate, and hydroxypropylmethylcellulose (HPMC) also have good mucoadhesive properties. Polyethylene glycols proved to have the weakest mucoadhesive properties. The negative relationship between the average molecular weight and the sample movement speed of the HEC and HPMC was established. Obtained data showed no direct influence of the polymer average molecular weight on the amount of adhesion. It was also noted that there is no strong correlation between the amount of adhesion and the sample movement speed of the experimental samples.
CONCLUSION: Based on the results of the study, it was suggested that the complex influences of the physical and chemical properties of the polymer on its mucoadhesive properties.
Download the full article here: Comparative Study of the Mucoadhesive Properties of Polymers for Pharmaceutical Use
or continue reading here: Bakhrushina E, Anurova M, Demina N, Kashperko A, Rastopchina O, Bardakov A, Krasnyuk I. Comparative Study of the Mucoadhesive Properties of Polymers for Pharmaceutical Use. Open Access Maced J Med Sci [Internet]. 2020Sep.30 [cited 2020Nov.9];8(A):639-45. Available from: https://www.id-press.eu/mjms/article/view/4930
Keywords: mucoadhesion, excipients, evaluation of mucoadhesive properties, polymers, xanthan gum, polyethyleneglycol
Physicochemical characteristics of polymers in this comparative study of mucoadhesive properties
| Type | Trade name, manufacturer | Recommended concentration, % | Viscosity |
|---|---|---|---|
| Hydroxyethylcellulose (HEC) | NATROSOL™ 250L Pharm, Ashland | 4–8 | 0.075–0.150 Pa∙s (5% solution) |
| Hydroxyethylcellulose (HEC) | NATROSOL™ 250G Pharm, Ashland | 4–8 | 0.25–0.4 Pa∙s (2% solution) |
| Hydroxyethylcellulose (HEC) | NATROSOL™ 250M Pharm, Ashland | 4–8 | 4.5–6.5 Pa∙s (2% solution) |
| Hydroxyethylcellulose (HEC) | NATROSOL™ 250H Pharm, Ashland | 4–8 | 1.5–2.5 Pa∙s (1% solution) |
| Hydroxyethylcellulose (HEC) | NATROSOL™ 250HHX Pharm, Ashland | 4–8 | 3.5–5.5 Pa∙s (1% solution) |
| Hydroxypropylmethylcellulose (HPMC) | Benecel™ K100LV PH DC, Ashland | 2–10 | 0.08–0.12 Pa∙s (2% solution) |
| Hydroxypropylmethylcellulose (HPMC) | Benecel™ E4M Pharm, Ashland | 2–10 | 2.7–5.04 Pa∙s (2% solution) |
| Hydroxypropylmethylcellulose (HPMC) | METOLOSE® 60SH, Shin-Etsu Chemical Co | 2–10 | 0.05–10 Pa∙s (2% solution) |
| Hydroxypropylmethylcellulose (HPMC) | Benecel™ K100MPH DC, Ashland | 2–10 | 75–140 Pa∙s (2% solution) |
| Hydroxypropylcellulose (HPC) | Klucel™ GF Pharm, Ashland | 5–20 | 0.15–0.4 Pa∙s (2% solution) |
| Sodium carboxymethylcellulose (sodium CMC) | Blanose® 7LPEP, Ashland | 4–8 | 0.025–0.05 Pa∙s (2% solution) |
| Sodium carboxymethylcellulose (sodium CMC) | Blanose® 7MF PH, Ashland | 4–8 | 1.5–2.5 Pa∙s (1% solution) |
| Sodium carboxymethylcellulose (sodium CMC) | Blanose® 9M31F PH, Ashland | 4–8 | 1.53.1 Pa∙s (2% solution) |
| Sodium alginates | Protanal® CR 8133, FMC BioPolymer | 5–10 | 0.1–0.3 Pa∙s(2% solution, pH 7.5) |
| Sodium alginates | Protanal® CR8223, FMC BioPolymer | 5–10 | 0.6–0.9 Pa∙s(1.25% solution, pH 7.5) |
| Sodium alginates | MANUCOL® LKX, IMCD LTD | 5–10 | 0.06-0.17 Pa∙s(1% solution, pH 7.5) |
| Xanthan gums | Grindsted® Xanthan 80, Dupont Nutrition & Health | 0.05–0.5 | 1.2–1.6 Pa∙s(1% solution in 1% KCl) |
| Xanthan gums | XANTURAL® 180 XANTHAN GUM,CP Kelco | 0.05–0.5 | 1.2–1.6 Pa∙s(1% solution in 1% KCl) |
| Carbomers | CARBOPOL® ETD 971P NF, Lubrizol | 0.5–0.7 | 4–11 Pa∙s (0.5% solution at pH 7.5) |
| Carbomers | CARBOPOL® 974P NF, Lubrizol | 0.5–0.7 | 29.4–39.4 Pa∙s (0.5% solution at pH 7.5) |
| Carbomers | CARBOPOL® ETD 2020 NF, Lubrizol | 0.5–0.7 | 47–77 Pa∙s(0.5% solution at pH 7.5) |
| Polyethylene glycols (PEG) | Polyglycol 400, «IREA2000» | 1–10 | 0.000039–0.000045 m /s (kinematic viscosity at t 40 ± 0.3°С) |
| Polyethylene glycols (PEG) | Polyglycol® 400S, Clariant | 0.5–20 | 0.000065–0.0001 m /s (kinematic viscosity at t 90 ± 0.3°С |