A unique pharmaceutical oil for solubility and oral bioavailability enhancement
White Paper New Maisine® CC
This white paper features Maisine® CC, Gattefossé’s tradename for glyceryl
monolinoleate (USP-NF), also known as corn oil mono-, di- and triglycerides.
This unique pharmaceutical oil has a long and successful history of use in
lipid-based formulation (LBF) for oral bioavailability enhancement.
In LBF Maisine® is associated with drug solubilization and increased oral
bioavailability and in certain cases mitigation of food effect and lymphatic
drug absorption – thereby reducing first-pass metabolism.
LBF is a viable approach for BCS Class II drugs, particularly those with high
Log P and good solubility in lipid excipients. LBF are classified in 4 types
(Pouton, 2000 and 2006), depending on the functionality of excipients – oily
vehicle, water soluble or insoluble surfactants and/or co-solvents – and
their respective concentration. Each type has advantages and drawbacks as
summarized in the graphic below. You find more details in the white paper.
Are you interested to receive more information or a sample? Just contact us