Lipids for solid dosage forms

YOUR FORMULATION CHALLENGE – IOI Oleo SOLUTIONS

According to the Biopharmaceutical Classification System (BCS), more than 70% of the APIs used in pharmaceutical preparations are difficult to formulate due to poor solubility and/or permeabilities, and the majority of drug candidates have similar characteristics. Formulating these APIs into stable forms and achieving satisfactory active delivery and dissolution profiles is a key challenge for galenic scientists.

IOI Oleo PHARMA offers a variety of vegetable-derived mono-, di- and triglycerides for a wide range of dosage forms such as tablets, capsules, granules or powders.

The lipid nature of our products gives them an inherent compatibility towards these problematic API categories and can help to solve the galenic formulation hurdles. Most of our excipients are multifunctional and suitable for various drug delivery systems. Adopted dosing is a trajectory to accentuate certain characteristics and functionalities depending on the specific formulation task.

Technologies and techniques such as SEDDS, SMEDDS, SNEDDS, SLN, Hot Melt Coating (taste masking), Hot Melt Extrusion or Hot Melt Granulation can be applied to enable delivery or enhance the dissolution profile of poorly soluble drugs.

Application Survey of Solid Dosage Forms

Approved Ingredients:

Vitamin preparations
Expectorants (e.g. ACC/ NAC)
Antiacidics (e.g. Hydrotalcite)
Antihelmintics (e.g. Moxidectin)
Non-steroidal anti-inflammatory drugs (e.g. ASA)
Non-opioid Analgesics (e.g. Paracetamol)

DYNASAN® – VERSATILE EXCIPIENTS FOR SOLID DOSAGE FORMS

The DYNASAN® product range is a family of high-purity monoacid triglycerides. Their chemical nature, raw materials, manufacturing and purification result in products with advantageous properties and impurity profile.

See the full brochure on “Lipids for solid dosage forms“ here

(click the picture to download the brochure)

Do you need some details or more information? Just fill in the contact form:

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Source: IOI Oleo GmbH brochure “Lipids for solid dosage forms”

Benefits for Tableting

Effective lubricant for tablet production in low concentrations (~ 0.5%) without the risks of fatty acid soaps
No influence on drug release up to a concentration of 1%, model drug Acetylsalicylic Acid
Higher concentrations from 2 to 5% increase the hydrophobic characteristics of tablet matrix and introduce retardation effects into oral dosage forms for sustained release characteristics
Enhances the tablet fracture stability due to an increased lubricity factor resulting from particle morphology and particle surface