Porous Particle Technology: Novel Approaches to Deep Lung Delivery – Chapter 5
Pulmonary Drug Delivery Systems: Material and Technological Advances
See the new book, edited by Piyush Pradeep Mehta and Vividha Dhapte -Pawar
Description:
- Brings new technologies & material advances together in pulmonary drug delivery systems
- Emphasis on critical aspects of pulmonary drug delivery through quality illustrations
- Includes challenges, evolving applications & future perspectives for pulmonary drug delivery
Chapter 5
Porous Particle Technology: Novel Approaches to Deep Lung Delivery
Porous particle technologies are widely used to deliver small and large molecular drugs to the lung for local and systemic treatment. Porous particles are able to deliver high drug payload via dry powder inhalers. The greatest advantages of porous particles are their simple dispersion and reduced aerodynamic diameter from their low density. When compared to non-porous particles, inhaled porous particles showed deep lung deposition. Carrier particle morphology has significant impacts on aerodynamic distribution. Additionally, large particle size also restricts immune response, which is beneficial in treating a number of lung diseases and makes them suitable carriers for antibiotics and anticancer molecules. The design of porous materials for controlled drug delivery is experimentally successful. The commercial application of porous particles for the pulmonary delivery of drugs with systemic or controlled release would be feasible when clinical outcomes are successful. Several technologies have been successfully employed in the production of porous particles, i.e., double-emulsion solvent evaporation technology, spray drying technology, supercritical fluid-assisted anti-solvent technology, spray freeze drying technology, and co-suspension delivery technology. Commercial porous particle technology includes PulmoSphere™ and Aerogel. In this chapter, the mentioned technologies are discussed along with examples of pertinent research and their applications for pulmonary delivery.
Sawatdee, S., Changsan, N., Srichana, T., Nanjwade, B. (2023). Porous Particle Technology: Novel Approaches to Deep Lung Delivery. In: Mehta, P.P., Dhapte -Pawar, V. (eds) Pulmonary Drug Delivery Systems: Material and Technological Advances. Springer, Singapore. https://doi.org/10.1007/978-981-99-1923-9_5
There will be to additional articles here soon with the remaining book chapter contents:
- See Chapter 7 – Chitosan-Based Particulates Carriers for Pulmonary Drug Delivery
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See Chapter 8 – Multifunctional Cyclodextrins Carriers for Pulmonary Drug Delivery: Prospects and Potential
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