The aim of this study was the design of novel S-protected thiolated hydroxyethyl cellulose (HEC) and the assessment of its mucoadhesive properties and biodegradability compared to the corresponding unmodified polymer. Thiolated HEC was S-protected via disulfide bond formation between 6-mercaptonicotinamide (6-MNA) and the thiol substructures of the polymer. In vitro screening of mucoadhesive properties was accomplished using two different methods: rotating cylinder studies and viscosity measurements. Moreover, biodegradability of these polymers by cellulase, xylanase and lysozyme was evaluated.
Highlights
• A thiolated hydroxyethyl cellulose-cysteamine (HEC-cys) conjugate was generated.
• Thiol groups were successfully protected using 6-mercaptonicotinamide.
• These modifications led to improved mucoadhesive properties.
• Thiolation and S-protection affected HEC susceptibility to enzymatic degradation by polysaccharidases.
• New conjugates were found to be non-toxic.
