Hayashibara Trehalose SG – Heat Stability brochure

Hayashibara ― A world leading supplier of pharmaceutical grade Trehalose

Founded as a starch syrup manufacturer in 1883, Hayashibara has grown into a company with strong research and development expertise, engaging in original and creative research. Utilizing our technological background in biotechnology and in-depth knowledge of saccharide production, Hayashibara became the first company in the world to succeed in the mass production of “Trehalose”, a unique disaccharide recognized as a beneficial excipient for the biopharmaceutical industry. In addition to trehalose, Hayashibara has been supplying for many years other high purity ingredients to the pharmaceutical industry worldwide.

TREHALOSE SG – Heat Stability

Material

TREHALOSE SG　Lot No. 4D04

Preparation of test solutions

TREHALOSE SG (dihydrate crystal) aqueous solutions were prepared at concentrations of 33, 40 and 50 g/L.

Heating conditions of solutions and evaluation of Trehalose content

Forty (40) mL each of the Trehalose solutions were poured into glass containers and heated at 122℃ for 0, 20, 40, 60 or 120 min. The solutions were analyzed by HPLC and the Trehalose content (%) was calculated by the Area normalization method.

Results

No changes in Trehalose content were observed even when the solutions were heated at 122℃ for 120 min.

Trehalose content (%) before and after heating

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Source: Hayashibara brochure “Trehalose SG – Heat Stability”

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