Hayashibara Trehalose SG – Heat Stability brochure
Hayashibara ― A world leading supplier of pharmaceutical grade Trehalose
Founded as a starch syrup manufacturer in 1883, Hayashibara has grown into a company with strong research and development expertise, engaging in original and creative research. Utilizing our technological background in biotechnology and in-depth knowledge of saccharide production, Hayashibara became the first company in the world to succeed in the mass production of “Trehalose”, a unique disaccharide recognized as a beneficial excipient for the biopharmaceutical industry. In addition to trehalose, Hayashibara has been supplying for many years other high purity ingredients to the pharmaceutical industry worldwide.
TREHALOSE SG – Heat Stability
Material
TREHALOSE SG Lot No. 4D04
Preparation of test solutions
TREHALOSE SG (dihydrate crystal) aqueous solutions were prepared at concentrations of 33, 40 and 50 g/L.
Heating conditions of solutions and evaluation of Trehalose content
Forty (40) mL each of the Trehalose solutions were poured into glass containers and heated at 122℃ for 0, 20, 40, 60 or 120 min. The solutions were analyzed by HPLC and the Trehalose content (%) was calculated by the Area normalization method.
Results
No changes in Trehalose content were observed even when the solutions were heated at 122℃ for 120 min.
Trehalose content (%) before and after heating
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Source: Hayashibara brochure “Trehalose SG – Heat Stability”
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