Lactose

MEGGLE announced the release of its new lactose product InhaLac® 145 yesterday. Pharma Excipients had the opportunity to speak with Dr. Constanze Müller, Manager Business Development Inhalation and one of the persons behind the development of InhaLac® 145 to get more background information on the…
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Abstract Objectives The aim of the project was to develop and characterise powders containing a probiotic (Lactiplantibacillus plantarum , Lacticaseibacillus rhamnosus, or Lactobacillus acidophilus) to be administered to the lung for the containment of pathogen growth in patients with lung…
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Wasserburg, Germany, December, 2023: Pharmaceutical lactose specialist MEGGLE will use the Drug Delivery to the Lungs (DDL) Conference in Edinburgh, Scotland, to launch InhaLac® 145 as the latest addition to its wide range of lactose-based dry powder inhalation (DPI) excipients. MEGGLE’s…
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Abstract This study developed a new dual delivery system of naringenin (NRG), a polyphenol, and doxofylline (DOX), a xanthine derivative, as an inhaled microsphere system. In this system, NRG has been first loaded into glyceryl tristearate-based solid lipid nanoparticles (NRG SLN), which were…
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The physics of tablets mixtures has gained much attention lately. The purpose of this work is to evaluate the compaction properties of Kollidon® SR (KSR) in the presence of different excipients such as Microcrystalline cellulose (MCC), Monohydrous lactose (MH Lactose), Poly (vinyl acetate) (PVA100),…
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Abstract Freeze-drying of biopharmaceutical products is the method of choice in order to improve their stability and storage conditions. Such Freeze-dried products are usually intended for parenteral route administration. However, many biopharmaceutical materials administered by parenteral route…
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Abstract Although the amount of amorphous content in lactose is low, its impact on the performance of a dry powder inhalation formulation might be high. Many formulators and regulatory agencies believe that the levels of amorphous content should be controlled once there is a relationship with the…
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Abstract Crystalline carriers such as dextrose, sucrose, galactose, mannitol, sorbitol, and isomalt have been reported to increase the solubility, and dissolution rates of poorly soluble drugs when employed as carriers in solid dispersions (SDs). However, synthetic polymers dominate the preparation…
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The supercritical antisolvent-fluidized bed coating process (SAS-FB) shows great potential as a technique to manufacture dry powder inhaler (DPI) that incorporate nanodrugs onto micronized matrix particles, capitalizing on the merits of both nanoparticle and pulmonary delivery. In this study,…
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Abstract Background Process intensification is a major hurdle in pharmaceutical process scale-up. Solvent removal strategies have limited the effectiveness of the overall stability of pharmaceutical formulations. The main aim of present review article is to focus on the use of the freeze-drying…
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