Transform Your Brick-Dust API into an Effective oral Drug Candidate with Apinovex Polymers

Lubrizol Apinovex™ polymers can be easily incorporated into your drug project via spray drying or other solvent-based processes. This novel excipient has a broad API and solvent compatibility to produce Amorphous Solid Dispersions (ASD) of your brick-dust API.

1. Unlock the Potential Of Your Brick-Dust API

It’s time to turn your insoluble, brick-dust APIs into efficient, differentiated oral treatments with Apinovex™ polymers.

There is a growing need for technologies that aid solubility enhancement and enable formulators to develop differentiated/IP-protected drug products.

Up to 90% of new chemical entities (NCEs) suffer from poor aqueous solubility and bioavailability.

2. Introducing Apinovex™ Polymers

Apinovex™ polymers are high molecular weight polyacrylic acid excipients designed to provide both processing and formulation benefits for spray dried ASDs. Apinovex™ polymers will be an indispensable tool in your formulator toolkit, enabling:

• Solubility enhancement of BCS Class II and IV APIs
• Smaller, more patient-friendly oral tablets
• More efficient API usage

3. Saving The Insoluble With Apinovex™ Polymers

Apinovex™ polymers build on Lubrizol’s decades-long legacy as a trusted excipient supplier. We are adapting to market needs by adding solubility enhancing excipients to our existing portfolio of efficient and differentiated solutions.

ApinovexTM excipients enable high drug loading of up to 80% via spray drying.

4. Apinovex™ Polymers For Patient-Centric Treatments

• High drug loading capacity leads to more efficient oral dosage forms.
• Achieve smaller tablets with the same concentration of API.
• Give patients new and improved development routes with 505(b)(2) formulations.

Formulate and manufacture with ease:

• Designed for established spray drying and solvent-based techniques.
• Soluble in water and common pharmaceutical solvents.
• Produces low viscosity solutions that increase ease of processing.

See the full infographic on “Transform Your Brick-Dust API into an Effective oral Drug Candidate” here

(click the picture to download the brochure)

MORE ON LUBRIZOL

Source: Lubrizol One Pager “Transform Your Brick-Dust API into an Effective oral Drug Candidate”

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