Paediatric

Abstract Diffuse intrinsic pontine glioma (DIPG) poses a significant treatment challenge in pediatric patients due to its aggressive nature and difficulty in crossing the blood–brain barrier with effective therapies. ONC201 (dordaviprone) shows promises in inducing apoptosis in cancer cells but…
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Abstract This study focused on developing and assessing the stability of pyrimethamine (PYM) sugar-free oral suspensions for treating congenital toxoplasmosis in the pediatric population, including neonates. Extemporaneous suspensions (2 mg/mL) were prepared using carboxymethylcellulose (CMC) or…
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Abstract Background: Propranolol, largely prescribed as an antihypertensive and antiarrhythmic drug in pediatrics, is characterized by a bitter taste and an astringent aftertaste. Currently, the therapy requires crushing of tablets for adults and their dispersion in water many times a day, leading…
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Abstract Orodispersible films (ODFs) have served as an emerging platform for the delivery of drugs in a convenient way. The production of ODFs with incorporated pellets may still be a challenging process due to problems to obtain proper homogeneity and deteriorating mechanical properties of the…
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Abstract The present study focused on the use of milk as a novel excipient for the manufacture of pharmaceutical dosage forms specifically designed for the pediatric population. Dairy milks with different fat contents were studied to deliver paracetamol orally. The World Health Organization…
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Abstract Ensuring children adhere to their prescribed medication can be challenging, particularly when a large number of medicines on the market consist of unpalatable drugs and difficult to swallow dosage forms. Sugar-based oromucosal films are easy to administer dosage forms across all age…
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This poster was presented at the EuPFI Conference 2024 by OnDosis AB: Background & Objective Today, oral solid medicines are often presented as relatively large tablets or capsules at one or a few dose strengths that do not offer the possibility for fine dose adjustments. The possibility to…
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Abstract The aim of the study was to propose pharmacy-compounded oral gels as a new and alternative dosage form that is attractive to children as having a better masking taste than syrups and reducing the risk of spilling. The application and physical properties of the gels prepared with cellulose…
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This poster was presented at the EuPFI 2024 in Rotterdam by Glatt Pharmaceutical Services: Introduction ➢Bitter tasting active pharmaceutical ingredients (API) for children require effective taste masking. ➢ Pellets are ideal dosage forms: A pre-defined dose of API can be applied by…
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Safe and Endogenous Compounds for Pharmaceutical Applications Phospholipids are ubiquitous, endogenous, and nutritional compounds. For pharmaceutical applications, phospholipids are safe and versatile excipients for any administration route. This is demonstrated by their long-standing use in…
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