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Dupont Pharma
Comprehensive powder flow characterization with reduced testing
Powder flow is a critical attribute of pharmaceutical blends to ensure tablet weight uniformity and production of tablets with consistent and reproducible properties. This study aims at characterizing different powder blends with a number of different rheologic techniques, in order to understand how…
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Characterization and Validation of a New 3D Printing Ink for Reducing Therapeutic Gap in Pediatrics…
Abstract
3D printing technology can be used to develop individualized medicines in hospitals and pharmacies, allowing a high degree of personalization and the possibility to adjust the dose of the API based on the quantity of material extruded. The main goal of incorporating this technology is to…
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The application of Near-Infrared Spatially Resolved Spectroscopy in scope of achieving continuous…
In scope of achieving real-time release of tablets, quality attributes need to be monitored and controlled through Process Analytical Technology tools such as near-infrared spectroscopy (NIRS). The authors evaluated the suitability of NIR-Spatially Resolved Spectroscopy (NIR-SRS) for continuous…
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Comparative Study of Selected Excipients’ Influence on Carvedilol Release from Hypromellose Matrix…
Solid dosage forms based on hypromellose (HPMC) with prolonged/extended drug release are very important from the research and industrial viewpoint. In the present research, the influence of selected excipients on carvedilol release performance from HPMC-based matrix tablets was studied. A…
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Comparison of scale-up strategies in twin-screw wet granulation
The aim of this study was to compare different scale-up strategies in twin-screw wet granulation and investigate the impact of the selected strategy on granule and tablet properties for a defined formulation. For the scale-up, a granulation process was transferred from a QbCon® 1 with a screw…
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Control oriented modeling of twin-screw granulation in the ConsiGma-25 production plant
ConsiGmaTM-25 is a continuous production plant integrating a twin-screw granulation, fluid bed drying, granule conditioning, and a tableting unit. The particle size distribution (PSD), active pharmaceutical ingredient (API) content, and liquid content of wet granules after twin-screw granulation…
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Understanding the role of magnesium stearate in lowering punch sticking propensity of drugs during…
The sticking of active pharmaceutical ingredient (API) to the surfaces of compaction tooling, frequently referred to as punch sticking, causes costly downtime or product failures in commercial tablet manufacturing. Magnesium stearate (MgSt) is a common tablet lubricant known to ameliorate the…
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Comparison of 5-ASA layered or matrix pellets coated with a combination of ethylcellulose and…
The aim of this study was to evaluate and optimize the combination of time and pH-dependent polymers as a single coating for the design of the colon-specific drug delivery system of 5-aminosalicylic acid (5-ASA) pellets. 5-ASA matrix pellets with a 70% drug load were prepared by the…
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Influence of talc and hydrogenated castor oil on the dissolution behavior of metformin-loaded…
Multi-unit pellet system (MUPS) is of great interest as it is amenable to customization. MUPS comprises multi-particulates, usually as pellets or spheroids, which can be coated with diffusion barrier coatings. One commonly used diffusion barrier coating is the methacrylic acid copolymer, which can…
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Enhanced geranylgeraniol stability and dissolution from self-emulsifying pellets containing the…
The vegetal species sucupira (Pterodon emarginatus Vogel) presents some diterpenes that have anti-inflammatory activities. However, diterpenes are poorly water-soluble compounds. The development of Self-Emulsifying Drug Delivery Systems (SEDDS) allows for obtaining a solid dosage form that maximizes…
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