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Phyllon
Feasibility of In-line monitoring of critical coating quality attributes via OCT: Thickness,…
The feasibility of Optical Coherence Tomography (OCT) for in-line monitoring of pharmaceutical film coating processes has recently been demonstrated. OCT enables real-time acquisition of high-resolution cross-sectional images of coating layers and computation of coating thickness. In addition,…
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Feasibility of In-line monitoring of critical coating quality attributes via OCT: Thickness,…
The feasibility of Optical Coherence Tomography (OCT) for in-line monitoring of pharmaceutical film coating processes has recently been demonstrated. OCT enables real-time acquisition of high-resolution cross-sectional images of coating layers and computation of coating thickness. In addition,…
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How to measure coating thickness of tablets: Method comparison of optical coherence tomography,…
Film coating of pharmaceutical dosage forms, such as tablets and pellets, can be used to tailor the drug release profile. With that regard, a uniform coating thickness of a single tablet (intra-tablet), all tablets (inter-tablet) and subsequent batches (inter-batch) is crucial. We present a method…
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Advanced Tablet Coating Development: Applying Optical Coherence Tomography (OCT) as a PAT Tool for…
Purpose: Novel tablet coating approaches include the development of continuous coating technologies. This requires a high level of automation to assure the quality and safety of the final coated product. Despite automation of control procedures also approaches of in-line process analytical…
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At-line Validation of Optical Coherence Tomography as In-line/At-line Coating Thickness Measurement…
Optical Coherence Tomography (OCT) is a promising technology for monitoring of pharmaceutical coating processes.
However, the pharmaceutical development and manufacturing require a periodic validation of the sensor’s accuracy. For this purpose, we propose polyethylene terephthalate (PET) films as…
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Measurement of granule layer thickness in a spouted bed coating process via optical coherence…
In this work a recently developed in-line measurement technique for monitoring of coating thickness was applied to a spray-coating process in a three-dimensional prismatic spouted bed.
The layer thickness was quantified with an optical coherence tomography (OCT) sensor positioned in front of the…
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Measure thickness, roughness and homogeneity of a film coating?
With OSeeT by Phyllon you can get up to 400 images of pellets in one minute and you can measure thickness, roughness and homogeneity of the filmcoating. For single layer, multi-layers, in-line or at-line, for pellets, mini-tablets, tablets, without chemometric calibration - just a direct…
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Shedding Light on Coatings
Real-time Monitoring of Coating Quality at Industrial Scale
Optical Coherence Tomography (OCT) is increasingly being used for studies of pharmaceutical film coating. OCT allows fast and non-destructive analysis of the coating thickness and quality via high-resolution cross-sectional images.…
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Measure coating thickness and characteristics in less than 2 minutes
With the OSeeT technology from Phyllon the measurement of tablet coating quality including
Coating thickness
Coating homogeneity
Surface roughness
can easily be measure at-line as shown in the Video below. The system works as an In-line application but also at line.
The…
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Optical coherence tomography as a novel tool for in-line monitoring of a pharmaceutical film-coating…
Optical coherence tomography (OCT) is a contact-free non-destructive high-resolution imaging technique based on low-coherence interferometry. This study investigates the application of spectral-domain OCT as an in-line quality control tool for monitoring pharmaceutical film-coated tablets. OCT…
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