Design Development and Evaluation of Nanostructured Lipid Carrier Loaded Emulgel of Voriconazole
Voriconazole is a second generation triazole derived from fluconazole. Voriconazole is used for the treatment of various fungal infections. Though it has excellent antifungal activity, there are several side effects associated with it. In order to overcome these limitations, nanostructures may be an excellent carrier for antifungal drugs. This study aimed to develop topical preparations of voriconazole for the treatment of mycotic infections of the skin. A nanostructured lipid carrier based emulgel formulation was developed and its physical characteristics, in vitro skin permeation and retention profiles were examined. A Voriconazole loaded NLC dispersion, consisting of stearic acid, oleic acid, SLS, Carbopol 940 was prepared by high pressure homogenization, and embedded into Carbopol 940 hydrogel.
The lipid nanoparticles in the emulgel were approximately 272.8nm in size, with a spherical shape and zeta potential of -22.40 mv. Amongst all the formulations, NLC loaded emulgel prepared with the 60% Stearic acid was found to have better encapsulation efficiency i.e. 97.5%. All the formulations were found to have good spreadability. The percentage of drug content was found to be within 95-99 %. The novel topical formulation reported here represents an alternative
treatment for skin infections such as candidiasis, with less potential for systemic adverse effects than oral therapy.
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Voriconazole was procured from Dr. Reddy’s Laboratories Ltd. (Hyderabad, India). The used lipids Stearic acid, Precirol ATO 5, Compritol 888 ATO, Glyceryl monostearate, Beeswaxwas purchased from the Research- Lab Fine Chem. Industry, Mumbaiand Loba chemie Pvt. Ltd, Mumbai. Castor oil, Almond oil, Sunflower oil and olive oil were obtained from local market, Colaba (South Mumbai India). Sodium Lauryl Sulphate and Carbopol were obtained from Molychem, Mumbai. Methanol, Ethanol and Triethanolamine were purchased from Research- Lab Fine Chem Industry, Mumbai. Distilled water was prepared in laboratory.
Pranali Baviskar, Prashant Patil, Dr. Rishikesh Bachav, Design Development and Evaluation of Nanostructured Lipid Carrier Loaded Emulgel of Voriconazole, International Journal of Pharmaceutical Research and Applications, Volume 7, Issue 6 Nov-Dec 2022, pp: 621-633 www.ijprajournal.com ISSN: 2456-4494
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