who advances drug delivery? we do. – pharmaceutical product and solution guide by Ashland

advancing drug delivery

Ashland’s pharmaceutical team prides itself on advancing drug delivery with sophisticated science-based solutions. Our global centers of excellence contain the latest equipment and our research scientists and formulators are ready to work with you from concept to commercialization.

We meet formulators’ needs by providing an unparalleled range of excipients and technologies, as well as longstanding polymer expertise and technical support for oral solids, liquids, and parenteral dosage forms.

Our solutions include:

o controlled release technologies
o tablet binders
o disintegrants
o solubilizers
o stabilizers
o rheology modifiers

Our full line of products combined with our global research and development capabilities can help deliver your drugs when and where they’re needed resulting in better outcomes for patients and pharmaceutical companies alike.

helping to ensure the efficacy, integrity and usability of pharmaceutical formulations

At Ashland, our number one goal is to help you apply pharmaceutical polymers in ways that ensure the efficacy, integrity and usability of your formulations. Explore how our molecular scientists, chemists, formulation development scientists and process engineers can help advance formulation development, support the commercialization of complex drug molecules, and reduce time to market. Our problem-solving team leverages a diverse polymer portfolio to enable comprehensive solutions, so when you’re ready to develop a formulation, we’ve got you covered.

cellulosics

klucel™ hydroxypropylcellulose

Klucel™ hydroxypropylcellulose (HPC) provides a remarkable set of physical properties for tablet binding, modified release, film coating, and hot melt extrusion. The versatility of Klucel™ HPC is apparent in a variety of pharmaceutical applications. Low molecular weight grades provide not only unmatched, efficient tablet binding but also adhesive and elastic tablet coating. They can also be used in melt-extrusion applications. High molecular weight grades are typically used for modified release, especially in matrix tablets.

benecel™ XR and XRF HPMC –  grades: K4M, K15M, K100M, K200M

Benecel™ XR and XRF are high-viscosity grades of HPMC with optimized polymer structure and particle morphology for use in matrix controlled-release systems.

features and benefits

• enhanced compactibility at high tableting speeds vs standard grades
• optimized polymer structure and particle morphology
• consistent particle size distribution and bulk density
• fine particle size grades available (XRF)

aqualon™ ethylcellulose and Ashland® EC pharm ultra

Aqualon™ ethylcellulose (EC) and Ashland® EC pharm ultra are nonionic ethyl ethers of cellulose, soluble in a wide range of organic solvents.

Aqualon™ EC is produced using an aqueous slurry based process while Ashland® EC is produced using an organic solvent based process. Typically, ethylcellulose is used as a non-swellable, insoluble component in matrix or coating systems. When water-soluble binders cannot be used in dosage processing because of water sensitivity of the active ingredient, ethylcellulose is often chosen.

vinyl pyrrolidones

polyplasdone™ crospovidone

Polyplasdone™ crospovidone superdisintegrants are synthetic, insoluble, but rapidly swellable, crosslinked homopolymers of N-vinyl-2-pyrrolidone. Polyplasdone ™ crospovidone particles are granular and porous compared with other superdisintegrants. The high surface area combined with unique chemistry results in high interfacial activity that enhances the dissolution of poorly water-soluble active pharmaceutical ingredients (APIs) in a way that is not possible with other disintegrant technologies.

bioresorbable polymers

viatel™ bioresorbable polymers

viatel™ features and benefits
o excellent product quality
o high purity
o stock and custom made to order grades available
o no residual solvents
o available in granule and powder forms

cyclodextrins

CAVAMAX*, CAVASOL*and cavitron™ cyclodextrins

The molecular structure of Cavamax, Cavasol and Cavitron cyclodextrins creates a bucket-like cavity that can complex with molecules or functional groups on molecules to improve solubility of poorly soluble compounds. The same mechanism makes these excipients capable of masking unpleasant taste/odor and stabilizing APIs that are prone to degradation.

film coating systems

aquarius™ film coating systems for immediate release

See the full brochure on “who advances drug delivery?” here

(click the picture to download the brochure)

Source: Ashland brochure “who advances drug delivery?”

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