All4Nutra
The solubility of poorly soluble drugs can be increased by using solubilizers such as polyethylene glycols (PEG), Tween 80 etc. These solublizers can be used to increase oral bioavailability of class II and class IV drugs. Often, these solubilizers are liquid in nature and can be challenging to formulate into solid dosage forms such as tablets and capsules. To address this, soft gelatin capsules have been used to deliver liquids. However, higher manufacturing time, poor yields and more required resources make soft gelatin capsules very costly.
Highlights
• Solid carrier for PEG-based drug delivery systems
• Transform liquids to easy to handle solids
• Increase liquid loading in solid dosage forms
• Release API completely from solid dosage forms
Syloid® XDP silicas are mesoporous, amorphous, silica gels with a unique morphology that create an excellent solid porous carrier for pharmaceutical formulations 1,2. The combined adsorption capacity, porosity, particle size, and density provide a tool to convert liquid ingredients into free flowing powder. The obtained liquid loaded Syloid® XDP silica creates formulations that are easy to manufacture and help improve efficacy of the final dosage form. In this application note, the role of Syloid® XDP silica as an adsorbent carrier is evaluated for delivery of PEG 400-drug solution in solid dosage forms.
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